Gene Expression Changes With Age

We are working on meta-analytic approaches to extract the age of patients from GEO descriptions and then statistically control for as many co-variates as possible to determine whether or not a gene increases or decreases with age. As with any meta-analytic approach, it is not a single trend but the weight of evidence that we attempt to assess. Shown here is an analysis of how CD248 changes with age in human peripheral blood, which was identified in two studies on gene expression changes with age as being decreased in both. As the figure shows, in 10 different large studies that record age with their control samples, after controlling for gender and microarray platform, CD248 consistently decreases with age.