The Program Enhancement Core of the Oklahoma Nathan Shock Center will provide both intellectual and organizational leadership in developing a research emphasis in Geroscience in Oklahoma City as well as the State of Oklahoma. The Oklahoma Nathan Shock Center will develop a Oklahoma Geroscience Consortium, which brings together all faculty in Oklahoma who are interested in aging and age-related diseases. The Consortium would involve faculty from the five research institutions in Oklahoma (OUHSC, OMRF, OKC-VAMC, OU-Norman, and OSU). To stimulate interaction among faculty, the Program Enhancement Core will organize an annual Conference of the Oklahoma Geroscience Consortium where faculty at the various institutions describe their research. In addition, Investigators receiving pilot grants from the Research Development Core are invited to attend the Conference and present their data.